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Although the timing of surgery is individual and variable, the literature often suggests between 4 and 12 weeks 6—8 weeks may be the ideal timing after starting conservative treatment given the recommended duration of some of the topical dosing regimens. Fissurectomy and isosorbide dinitrate for chronic fissure in ano not responding to conservative treatment. Examination and diseases of the anorectum. Glyceryl trinitrate ointment for the treatment of chronic anal fissure: All the 25 patients with complete remission had a mean follow-up of Topical diltiazem ointment in the treatment of chronic anal fissure. Methods The study protocol was approved by the Ethics Committee of the Central Hospital of Thessaloniki, and all patients signed an informed consent.
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Is topical nifedipine effective for chronic anal fissures?

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